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KMID : 1098420200280040287
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Korean Journal of Medicinal Crop Science
2020 Volume.28 No. 4 p.287 ~ p.297
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Anti-hyperglycemic Effect of Bangpungtongseong-san on Type II Diabetes Animal Models
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Ko Moon-Hee
Cho Hyun-Woo
Nho Jong-Hyun
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Abstract
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Background: Type II diabetes is considered as one of the common diseases. Bangpungtongseongsan (BPS) has been used as a traditional medicine for treating obesity and hypertension in Korea. According to previous reports, it has anti-obesity, anti-chronic asthma, anti-oxidant, and antiinflammatory properties. However, the effects of BPS on type II diabetes have not yet been elucidated. Thus, in this sutudy, we evaluated the water extracts of BPS using type II diabetes animal models.
Methods and Results: Each group was orally administered with BPS (170, 850 and 1,700 ㎎/㎏) for approximately 13 weeks. A mixture of 150 ㎎/㎏ metformin and 10 ㎎/㎏ sitagliptin (MS) was used as a positive control. The glycated hemoglobin (HbA1c) and glucose levels, and hematological parameters including blood urine nitrogen, creatinine, low density lipoprotein and total cholesterol, were measured using blood samples. Treatment with 170 ㎎/㎏ BPS decreased the HbA1c and glucose levels in blood without affecting the weights of the animals. However, threatment with 1,700 ㎎/㎏ BPS reduced the weights and fatty liver, and increased the blood glucose level in type II diabetes animal models
Conclusions: These results indicate that a low dose of BPS for 13 weeks, which reduces HbA1c and blood glucose levels, could be used for the treatment of type II diabetes. However, further studies are required to elucidate how active ingredients of BPS influence HbA1c and glucose levels in blood.
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KEYWORD
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Bangpungtongseong-san, Type II Diabetes, Traditional Medicine
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